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fogyasztás Orvos megsért overall mutation load and p53 mutations visszatartása Újdonság Különféle

TP53 mutational landscape of metastatic head and neck cancer reveals  patterns of mutation selection - eBioMedicine
TP53 mutational landscape of metastatic head and neck cancer reveals patterns of mutation selection - eBioMedicine

Low-burden TP53 mutations in CLL: clinical impact and clonal evolution  within the context of different treatment options - ScienceDirect
Low-burden TP53 mutations in CLL: clinical impact and clonal evolution within the context of different treatment options - ScienceDirect

Homogenous TP53mut-associated tumor biology across mutation and cancer  types revealed by transcriptome analysis | Cell Death Discovery
Homogenous TP53mut-associated tumor biology across mutation and cancer types revealed by transcriptome analysis | Cell Death Discovery

IJMS | Free Full-Text | Do Mutations Turn p53 into an Oncogene?
IJMS | Free Full-Text | Do Mutations Turn p53 into an Oncogene?

Analysis of P53 mutations and their expression in 56 colorectal cancer cell  lines | PNAS
Analysis of P53 mutations and their expression in 56 colorectal cancer cell lines | PNAS

Mutant p53 Gain of Function in Two Mouse Models of Li-Fraumeni Syndrome:  Cell
Mutant p53 Gain of Function in Two Mouse Models of Li-Fraumeni Syndrome: Cell

Probability Distributions of p53 Mutations and Their Corresponding Shannon  Entropies in Different Cancer Cell Types | SpringerLink
Probability Distributions of p53 Mutations and Their Corresponding Shannon Entropies in Different Cancer Cell Types | SpringerLink

A TP53-Associated Immune Prognostic Signature for the Prediction of Overall  Survival and Therapeutic Responses in Muscle-Invasive Bladder Cancer -  Frontiers
A TP53-Associated Immune Prognostic Signature for the Prediction of Overall Survival and Therapeutic Responses in Muscle-Invasive Bladder Cancer - Frontiers

Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule  Stabilizers: the Y220X Paradigm | ACS Chemical Biology
Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm | ACS Chemical Biology

Mutations of the p53 Gene as a Prognostic Factor in Aggressive B-Cell  Lymphoma | NEJM
Mutations of the p53 Gene as a Prognostic Factor in Aggressive B-Cell Lymphoma | NEJM

TP53 exon-6 truncating mutations produce separation of function isoforms  with pro-tumorigenic functions | eLife
TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions | eLife

Prognostic value of TP53 mutation location in breast cancer | CMAR
Prognostic value of TP53 mutation location in breast cancer | CMAR

Mutational processes shape the landscape of TP53 mutations in human cancer  | Nature Genetics
Mutational processes shape the landscape of TP53 mutations in human cancer | Nature Genetics

High prevalence of TP53 loss and whole-genome doubling in early-onset  colorectal cancer | Experimental & Molecular Medicine
High prevalence of TP53 loss and whole-genome doubling in early-onset colorectal cancer | Experimental & Molecular Medicine

TP53 mutational landscape of metastatic head and neck cancer reveals  patterns of mutation selection - eBioMedicine
TP53 mutational landscape of metastatic head and neck cancer reveals patterns of mutation selection - eBioMedicine

Frontiers | Promising New Tools for Targeting p53 Mutant Cancers: Humoral  and Cell-Based Immunotherapies
Frontiers | Promising New Tools for Targeting p53 Mutant Cancers: Humoral and Cell-Based Immunotherapies

Germline TP53 mutations undergo copy number gain years prior to tumor  diagnosis | Nature Communications
Germline TP53 mutations undergo copy number gain years prior to tumor diagnosis | Nature Communications

p53 Is the Most Frequently Mutated Gene in Cancer, but Can We Target It?
p53 Is the Most Frequently Mutated Gene in Cancer, but Can We Target It?

Survival of patients with p53 mutations in the DNA-binding motifs... |  Download Scientific Diagram
Survival of patients with p53 mutations in the DNA-binding motifs... | Download Scientific Diagram

Gain of function in somatic TP53 mutations is associated with immune‐rich  breast tumors and changes in tumor‐associated macrophages - Behring - 2019  - Molecular Genetics & Genomic Medicine - Wiley Online Library
Gain of function in somatic TP53 mutations is associated with immune‐rich breast tumors and changes in tumor‐associated macrophages - Behring - 2019 - Molecular Genetics & Genomic Medicine - Wiley Online Library

p53 Is the Most Frequently Mutated Gene in Cancer, but Can We Target It?
p53 Is the Most Frequently Mutated Gene in Cancer, but Can We Target It?

Omics analyses of a somatic Trp53R245W/+ breast cancer model identify  cooperating driver events activating PI3K/AKT/mTOR signaling | PNAS
Omics analyses of a somatic Trp53R245W/+ breast cancer model identify cooperating driver events activating PI3K/AKT/mTOR signaling | PNAS

Mutant p53 achieved Gain-of-Function by promoting tumor growth and immune  escape through PHLPP2/AKT/PD-L1 pathway
Mutant p53 achieved Gain-of-Function by promoting tumor growth and immune escape through PHLPP2/AKT/PD-L1 pathway

Gastrointestinal Disorders | Free Full-Text | Prognostic Impact of TP53  Mutations and Tumor Mutational Load in Colorectal Cancer
Gastrointestinal Disorders | Free Full-Text | Prognostic Impact of TP53 Mutations and Tumor Mutational Load in Colorectal Cancer

LRP1B or TP53 mutations are associated with higher tumor mutational burden  and worse survival in hepatocellular carcinoma
LRP1B or TP53 mutations are associated with higher tumor mutational burden and worse survival in hepatocellular carcinoma

Diverse rescue potencies of p53 mutations to ATO are predetermined by  intrinsic mutational properties | Science Translational Medicine
Diverse rescue potencies of p53 mutations to ATO are predetermined by intrinsic mutational properties | Science Translational Medicine

The p53 network: cellular and systemic DNA damage responses in cancer and  aging: Trends in Genetics
The p53 network: cellular and systemic DNA damage responses in cancer and aging: Trends in Genetics

Mutant p53 elicits context-dependent pro-tumorigenic phenotypes | Oncogene
Mutant p53 elicits context-dependent pro-tumorigenic phenotypes | Oncogene